Review
  • Potential of 3D Bioprinting Techniques in Tissue Engineering

  • Yunjeh Ko, Chun-Ho Kim*, and Oh Hyeong Kwon†

  • Department of Polymer Science and Engineering, Kumoh National Institute of Technology, Gumi, Gyeongbuk 39177, Korea
    *Laboratory of Tissue Engineering, Korea Institute of Radiological and Medical Sciences, Nowon, Seoul 01812, Korea

  • 조직공학에서의 3D 바이오프린팅 기술의 잠재력

  • 고윤제 · 김천호* · 권오형†

  • 금오공과대학교 고분자공학과, *한국원자력의학원 조직공학연구실

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

Abstract

Three-dimensional (3D) bioprinting is an additive manufacturing technique used for the 3D modeling of biological constructs containing cells. In particular, customized artificial tissues (bone/cartilage, skin/muscle, blood vessels, organs system) with precise and uniform structures can be created using computer-aided design, 3-axis plotting instrument, and optimum physicochemical cell-laden bioinks. The main bioprinting procedures are three stages of modeling, solid freeform fabrication, and post-maturation. This review introduced the basic principles and components of 3D bioprinting and potential research cases to summarize the challenging agenda in practical tissue engineering and medical applications.


3차원(3D) 바이오프린팅은 세포를 함유한 생물학적 구조물의 입체적 조형에 사용되는 적층제작술이다. 특히, CAD(computer-aided design)와 3축 출력기구 및 세포를 함유한 최적의 물리화학적 바이오잉크를 사용하여 정확하고 균일한 구조의 맞춤형 인공조직(뼈/연골, 피부/근육, 혈관, 장기 시스템)을 제작할 수 있다. 바이오프린팅의 주요절차는 모델링, 고체 자유형상 제작 및 후성숙의 세 단계로 진행된다. 본 리뷰에서는 3D 바이오프린팅의 기본원리, 구성요소 및 잠재력 있는 연구사례들을 소개하고 실제적인 조직공학 및 의료적 응용분야에서의 도전과제를 요약하였다.


Keywords: additive manufacturing, 3D bioprinting, bioink, tissue engineering, medical.

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2022; 46(3): 301-317

    Published online May 25, 2022

  • 10.7317/pk.2022.46.3.301
  • Received on Mar 14, 2022
  • Revised on Apr 1, 2022
  • Accepted on Apr 4, 2022

Correspondence to

  • Oh Hyeong Kwon

  • Department of Polymer Science and Engineering, Kumoh National Institute of Technology, Gumi, Gyeongbuk 39177, Korea

  • E-mail: ohkwon@kumoh.ac.kr