• Degradation Behaviors of Poly(L-lactic acid) Microspheres
  • Lie Ma*,**,#, Ailin Shen**,#, Jiayu Gu*, Honghua Hu**, Guoshou Jin**, Jiangfeng Cai**, Bing Feng**, Xiaodong He**,†  , and Jun Ling*,† 

  • *MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, China
    **Zhejiang Wedu Medical Co., Ltd., Hengdian Industrial Zone, Dongyang 322118, China

  • 폴리(L-락트산) 마이크로스피어의 분해 거동
  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.


References
  • 1. Taib, N.-A. A. B.; Rahman, M. R.; Huda, D.; Kuok, K. K.; Hamdan, S.; Bakri, M. K. B.; Julaihi, M. R. M. B.; Khan, A. A Review on Poly Lactic Acid (PLA) as a Biodegradable Polymer. Polym. Bull. 2023, 80, 1179-1213.
  •  
  • 2. Anderson, J. M.; Shive, M. S. Biodegradation and Biocompatibility of PLA and PLGA Microspheres. Adv. Drug Delivery Rev. 1997, 28, 5-24.
  •  
  • 3. Qi, F.; Wu, J.; Li, H.; Ma, G. Recent Research and Development of PLGA/PLA Microspheres/nanoparticles: A Review in Scientific and Industrial Aspects. Front. Chem. Sci. Eng.2019, 13, 14-27.
  •  
  • 4. Seol, E.; Yoon, K.; Lee, H.; Jo, S.-J.; Park, J., II; Hwang, S.-J.; Cho, C.-W. Donepezil-loaded Poly(D,L-lactic acid) Microspheres for Potent and Sustained Drug Release in the Treatment of Alzheimer’s Disease. Polym. Korea 2022, 46, 238-245.
  •  
  • 5. Qiu, Q.-Q.; Ducheyne, P.; Ayyaswamy, P. S. New Bioactive, Degradable Composite Microspheres As Tissue Engineering Substrates. J. Biomed. Mater. Res. 2000, 52, 66-76.
  •  
  • 6. Shi, X.; Jiang, J.; Sun, L.; Gan, Z. Hydrolysis and Biomineralization of Porous PLA Microspheres and Their Influence on Cell Growth. Colloid Surface B. 2011, 85, 73-80.
  •  
  • 7. Lopes, M. S.; Jardini, A. L.; Filho, R. M. Poly(Lactic Acid) Production for Tissue Engineering Applications. Procedia Eng. 2012, 42, 1402-1413.
  •  
  • 8. Ballin, A. C.; Brandt, F. S.; Cazzaniga, A. Dermal Fillers: An Update. Am. J. Clin. Dermatol. 2015, 16, 271-283.
  •  
  • 9. McKeown, P.; Jones, M. D. The Chemical Recycling of PLA: A Review. In Sustainable Chemistry, 2020, 1, 1-22.
  •  
  • 10. Zaaba, N. F.; Jaafar, M. A Review on Degradation Mechanisms of Polylactic Acid: Hydrolytic, Photodegradative, Microbial, and Enzymatic Degradation. Polym. Eng. Sci. 2020, 60, 2061-2075.
  •  
  • 11. Hegyesi, N.; Zhang, Y.; Kohári, A.; Polyák, P.; Sui, X.; Pukánszky, B. Enzymatic Degradation of PLA/cellulose Nanocrystal Composites. Ind. Crop. Prod. 2019, 141, 111799.
  •  
  • 12. Karamanlioglu, M.; Preziosi, R.; Robson, G. D. Abiotic and Biotic Environmental Degradation of the Bioplastic Polymer Poly(lactic acid): A Review. Polym. Degrad. Stabil. 2017, 137, 122-130.
  •  
  • 13. Qi, X.; Ren, Y.; Wang, X. New Advances in the Biodegradation of Poly(lactic) Acid. Int. Biodeterior. Biodegrad. 2017, 117, 215-223.
  •  
  • 14. Lee, S. H.; Kim, I. Y.; Song, W. S. Biodegradation of Polylactic Acid (PLA) Fibers Using Different Enzymes. Macromol. Res. 2014, 22, 657-663.
  •  
  • 15. Satti, S. M.; Shah, A. A.; Auras, R.; Marsh, T. L. Isolation and Characterization of Bacteria Capable of Degrading Poly(lactic acid) at Ambient Temperature. Polym. Degrad. Stabil.2017, 144, 392-400.
  •  
  • 16. Kliem, S.; Kreutzbruck, M.; Bonten, C. Review on the Biological Degradation of Polymers in Various Environments. Materials, 2020, 13, 4586.
  •  
  • 17. Li, X.; Deng, X.; Yuan, M.; Xiong, C.; Huang, Z.; Zhang, Y.; Jia, W. In Vitro Degradation and Release Profiles of Poly-D,L-lactide-poly(ethylene glycol) Microspheres with Entrapped Proteins. J. Appl. Polym. Sci. 2000, 78, 140-148.
  •  
  • 18. Dorati, R.; Genta, I.; Colonna, C.; Modena, T.; Pavanetto, F.; Perugini, P.; Conti, B. Investigation of the Degradation Behaviour of Poly(ethylene glycol-co-D,L-lactide) Copolymer. Polym. Degrad. Stabil. 2007, 92, 1660-1668.
  •  
  • 19. Jh, I.; Yk, L.; Km, H. Preparation and Characterization of PEG-PLA(PLGA) Micelles for Solubilization of Pioglitazone. Polym. Korea 2008, 32, 143-149.
  •  
  • 20. H, H.; Yh, C.; Sc, J.; B, L.; Ms, K.; G, K.; Hb, L. Synthesis and Characterization of Biodegradable MethoxyPoly(ethylene glycol)-Poly(ε-caprolactone-co-L-lactide) Block Copolymers. Polym. Korea 2006, 30, 28-34.
  •  
  • 21. Peng, H.; Ling, J.; Liu, J.; Zhu, N.; Ni, X.; Shen, Z. Controlled Enzymatic Degradation of Poly(ɛ-caprolactone)-based Copolymers in the Presence of Porcine Pancreatic Lipase. Polym. Degrad. Stabil. 2010, 95, 643-650.
  •  
  • 22. Cai, Q.; Shi, G.; Bei, J.; Wang, S. Enzymatic Degradation Behavior and Mechanism of Poly(lactide-co-glycolide) Foams by Trypsin. Biomaterials 2003, 24, 629-638.
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2024 Impact Factor : 0.6
  • Indexed in SCIE

This Article

  • 2026; 50(2): 220-225

    Published online Mar 25, 2026

  • 10.7317/pk.2026.50.2.220
  • Received on Jul 23, 2025
  • Revised on Oct 20, 2025
  • Accepted on Nov 2, 2025

Correspondence to

  • Xiaodong He** , and Jun Ling*
  • *MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, China
    **Zhejiang Wedu Medical Co., Ltd., Hengdian Industrial Zone, Dongyang 322118, China

  • E-mail: xd.he@wedumedical.com, lingjun@zju.edu.cn