• Design and Synthesis of Silicone Monomers for Advanced Contact Lens Application
  • Sun-Woo Sim, Yoon Jung Jang*,† , and Hyun Mee Lee

  • Department of Optometry and Vision Science, Daegu Catholic University, Gyeongbuk 38430, Korea
    *Chunma College of General Studies, Yeungnam University, Gyeongbuk 38541, Korea

  • 실리콘 단량체 합성 및 중합체의 콘택트렌즈 활용성
  • 심선우 · 장윤정*,† · 이현미

  • 대구가톨릭대학교 안경광학과, *영남대학교 천마학부대학 교양학부

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.


References
  • 1. Van Beek, M.; Jones, L.; Sheardown, H. Hyaluronic Acid Containing Hydrogels for the Reduction of Protein Adsorption. Biomaterials 2008, 29, 780-789.
  •  
  • 2. Santos, L.; Rodrigues, D.; Lira, M.; Oliveira, M. E. C. R.; Oliveira, R.; Vilar, E. Y.; Azeredo, J. The Influence of Surface Treatment on Hydrophobicity, Protein Adsorption and Microbial Colonisation of Silicone Hydrogel Contact Lenses. Cont. Lens Anterior Eye 2007, 30, 183-188.
  •  
  • 3. Guillon, M. Are Silicone Hydrogel Contact Lenses More Comfortable Than Hydrogel Contact Lenses? Eye & Contact Lens 2013, 39, 86-92.
  •  
  • 4. Cheng, L.; Muller, S. J.; Radke, C. J. Wettability of Silicone-hydrogel Contact Lenses in the Presence of Tear-film Components. Curr. Eye Res. 2004, 28, 93-108.
  •  
  • 5. Kazemi Ashtiani, M.; Zandi, M.; Shokrollahi, P.; Ehsani, M.; Baharvand, H. Surface Modification of Poly(2‐hydroxyethyl methacrylate) Hydrogel for Contact Lens Application. Polym. Adv. Technol. 2018, 29, 1227-1233.
  •  
  • 6. Fatt, I. New Physiological Paradigms to Assess the Effect of Lens Oxygen Transmissibility on Corneal Health. Eye & Contact Lens 1996, 22, 25-29.
  •  
  • 7. Pozuelo, J.; Compañ, V.; González-Méijome, J. M.; González, M.; Mollá, S. Oxygen and Ionic Transport in Hydrogel and Silicone-hydrogel Contact Lens Materials: An Experimental and Theoretical Study. J. Membr. Sci. 2014, 452, 62-72.
  •  
  • 8. Vázquez, B.; San Roman, J.; Peniche, C.; Cohen, M. E. Polymeric Hydrophilic Hydrogels with Flexible Hydrophobic Chains. Control of the Hydration and Interactions with Water Molecules. Macromolecules 1997, 30, 8440-8446.
  •  
  • 9. Efron, N.; Morgan, P. B.; Cameron, I. D.; Brennan, N. A.; Goodwin, M. Oxygen Permeability and Water Content of Silicone Hydrogel Contact Lens Materials. Optometry Vision Sci. 2007, 84, E328-E337.
  •  
  • 10. Holden, B. A.; Mertz, G. W. Critical Oxygen Levels to Avoid Corneal Edema for Daily and Extended Wear Contact Lenses. Invest. Ophthalmol. Vis. Sci. 1984, 25, 1161-1167.
  •  
  • 11. Benjamin, W. J. Downsizing of Dk and DkL: The Difficulty in Using hPa Instead of MmHg. International Contact Lens Clinic 1996,23, 188-189.
  •  
  • 12. Giedd, B. Understanding the Nuances of Contact Lens Materials. Contact Lens Spectrum 1999,14, 23-28.
  •  
  • 13. Nichols, J. J.; Sinnott, L. T. Tear Film, Contact Lens, and Patient-related Factors Associated with Contact Lens–related Dry Eye. Invest. Ophthalmol. Vis. Sci. 2006, 47, 1319-1328.
  •  
  • 14. Mani, S.; Khabaz, F.; Godbole, R. V.; Hedden, R. C.; Khare, R. Structure and Hydrogen Bonding of Water in Polyacrylate Gels: Effects of Polymer Hydrophilicity and Water Concentration. J. Phys. Chem. B 2015, 119, 15381-15393.
  •  
  • 15. Nicolson, P. C.; Vogt, J. Soft Contact Lens Polymers: An Evolution. Biomaterials 2001, 22, 3273-3283.
  •  
  • 16. Tranoudis, I.; Efron, N. Water Properties of Soft Contact Lens Materials. Contact Lens and Anterior Eye 2004, 27, 193-208.
  •  
  • 17. Byron, M. L.; Variano, E. A. Refractive-index-matched Hydrogel Materials for Measuring Flow-structure Interactions. Exp. Fluids 2013, 54, 1456.
  •  
  • 18. Pavlyuchenko, V. N.; Sorochinskaya, O. V.; Ivanchev, S. S.; Khaikin, S. Y.; Trounov, V. A.; Lebedev, V. T.; Sosnov, E. A.; Gofman, I. V. New Silicone Hydrogels Based on Interpenetrating Polymer Networks Comprising Polysiloxane and Poly(vinyl alcohol) Networks. Polym. Adv. Technol. 2009, 20, 367-377.
  •  
  • 19. Lonescu, A. M.; Talaveron, A.; Cardona, J. C.; López, S.; Rodríguez-Águila, A. B.; Ruiz-López, J., Perez, M. M.; Ghinea, R. Evaluation of the optical properties of two different types of soft contact lenses: hydrogel and silicone-hydrogel. Proc. SPIE 11207, Fourth International Conference on Applications of Optics and Photonics, Lisbon, Portugal, October 3, 2019, 112071P.
  •  
  • 20. Alhakimi, M. The Synthesis and Characterization of Monomers for Contact Lens Materials. Ph. D. Thesis, McMaster University: Hamilton, December, 2024.
  •  
  • 21. Zeng, J.; Xu, Q.; Nie, Y.; Han, X.; Jiang, Y. Preparation and Properties of Silicone Hydrogel Contact Lens Based on PDMS-PU Macromer. Colloid Polym. Sci. 2025, 303, 793-804.
  •  
  • 22. Lin, C.; Cho, H.; Yeh, Y.; Yang, M. Improvement of the Surface Wettability of Silicone Hydrogel Contact Lenses via Layer-by-layer Self-assembly Technique. Colloids Surf. B: Biointerfaces 2015, 136, 735-743.
  •  
  • 23. Jones, L.; Senchyna, M.; Glasier, M.; Schickler, J.; Forbes, I.; Louie, D.; May, C. Lysozyme and Lipid Deposition on Silicone Hydrogel Contact Lens Materials. Eye & Contact Lens 2003, 29, S75-S79.
  •  
  • 24. Lai, Y. Role of Bulky Polysiloxanylalkyi Methacrylates in Oxygen‐permeable Hydrogel Materials. J. Appl. Polym. Sci. 1995, 56, 317-324.
  •  
  • 25. Kim, H. J.; Kim, S.; Kim, J. A Study on Improvement of Wettability and Comfort in Contact Lens with Hyaluronic Acid. J. Korean Ophthalmic Opt. Soc. 2011, 16, 255-264.
  •  
  • 26. Min, I.; Lee, G. M.; Kim, H.; Ryu, G. Development of Hydrogel Contact Lenses Surface-Functionalized with PEG chains for Protein Adsorption Studies. Korean J. Vis. Sci. 2019, 21, 621-629.
  •  
  • 27. Kim, Y.; Park, B.; Kim, H.; Choi, J.; Moon, J.; Oh, T.; Ma, J.; Kim, K. Retrospective Observational Study for Effectiveness of Inmok-tang on Dry Eye Syndrome. Herb. Formula Sci. 2019, 27, 285-297.
  •  
  • 28. Tran, N.; Yang, M. Synthesis and Characterization of Soft Contact Lens Based on the Combination of Silicone Nanoparticles with Hydrophobic and Hydrophilic Monomers. J. Polym. Res. 2019, 26, 143.
  •  
  • 29. Song, J. M.; Kwon, S.; Cho, E. J. Correlation Between Tear Volume and Tear Film Stability and Protein Amount Deposited on Soft Contact Lenses in Dry Eyes. J. Korean Ophtalmic Opt. Soc. 2019, 24, 11-19.
  •  
  • 30. Nichols, J. J.; Starcher, L. Contact Lenses 2019. Contact Lens Spectrum 2018, 33, 20-25.
  •  
  • 31. Kim, J.; Cha, E.; Park, J. Recent Advances in Smart Contact Lenses. Adv. Mater. Technol. 2020, 5, 1900728.
  •  
  • 32. Wang, K.; Hao, Y.; Wang, Y.; Chen, J.; Mao, L.; Deng, Y.; Chen, J.; Yuan, S.; Zhang, T.; Ren, J. Functional Hydrogels and Their Application in Drug Delivery, Biosensors, and Tissue Engineering. Int. J. Polym. Sci. 2019, 2019, 3160732.
  •  
  • 33. Liesegang, T. J. Physiologic Changes of the Cornea with Contact Lens Wear. Eye & Contact Lens 2002, 28, 12-27.
  •  
  • 34. Read, S. A.; Collins, M. J. Diurnal Variation of Corneal Shape and Thickness. Optometry Vision Sci. 2009, 86, 170-180.
  •  
  • 35. Park, Y.; Lee, G.; Park, J.; Jeong, B.; Lee, K. The Long-term Effects of Soft Contact Lens Wear on Corneal Thickness, Curvature and Endothelium. J. Korean Ophthalmol. Soc.2005, 945-953.
  •  
  • 36. González-Méijome, J. M.; Lira, M.; López-Alemany, A.; Almeida, J. B.; Oliveira, M. E. Refractive Index and Equilibrium Water Content of Conventional and Silicone Hydrogel Contact Lenses. Ophthalmic Physiol. Opt. 2006, 26, 151-157.
  •  
  • 37. Tyagi, G.; Collins, M.; Read, S.; Davis, B. Regional Changes in Corneal Thickness and Shape with Soft Contact Lenses. Optometry Vision Sci. 2010, 87, 567-575.
  •  
  • 38. Zhang, F. A Novel Use of Confocal Microscopy to Study Lysozyme Sorption to Silicone Hydrogel and Conventional Hydrogel Contact Lens Materials. M.A.Sc. Thesis, McMaster University, Hamilton, 2006.
  •  
  • 39. Woo, C.; Lee, H. M. Change of Corneal Shape with Soft Contact Lens Type. Journal of Korean Ophthalmic Optics Society 2014, 19, 111-120.
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2024 Impact Factor : 0.6
  • Indexed in SCIE

This Article

  • 2026; 50(2): 253-260

    Published online Mar 25, 2026

  • 10.7317/pk.2026.50.2.253
  • Received on Aug 29, 2025
  • Revised on Nov 3, 2025
  • Accepted on Nov 3, 2025

Correspondence to

  • Yoon Jung Jang* , and Hyun Mee Lee
  • Department of Optometry and Vision Science, Daegu Catholic University, Gyeongbuk 38430, Korea
    *Chunma College of General Studies, Yeungnam University, Gyeongbuk 38541, Korea

  • E-mail: jyj5014@ynu.ac.kr, hmlee@cu.ac.kr