• Miniemulsion Polymerization of Poly(viny acetate) Nanoparticles Stabilized by Hexadecane
  • Park SJ, Kim KS
  • 헥사데칸에 의해 안정된 폴리(비닐 아세테이트) 나노입자의 미니유화 중합
  • 박수진, 김기석
Abstract
Poly(vinyl acetate) (PVAc) nanoparticles were synthesized in oil/water miniemulsion polymerization in the presence of low amount of hexadecane as a cosurfactant. The nanoparticles were tested to apply as a drug carrier. The shape of nanoparticles was observed by scanning electron microscopy, and the average particle size and size distribution were examined by particle size analyzer. Inclusion of antibiotic drugs into the nanoparticles was confirmed by CHO, C=O, and OH peak of FT-IR. Size of the nanoparticles were adjusted between 80 ~ 300 nm by changing the homogenization rate and amount of cosurfactant and surfactant. The monomer droplets prepared by miniemulsion method using a cosurfactant were homogeneous and stable compared with those prepared by conventional emulsion polymerization. This might be occurred due to the prevention of Ostwald ripening and coalescence between droplets by using hexadecane as a cosurfactant.

폴리(비닐 아세테이트) (PVAc) 나노입자는 공유화제로 헥사데칸을 사용한 수중유형 미니유화 중합법을 이용하여 제조하였고, 제조 조건에 따른 나노입자는 약물 전달체로서의 가능성을 고찰하였다. 제조된 나노입자의 형태를 SEM으로 관찰하였고, 평균 입자크기와 입자의 분포는 입도 분석기로 측정하였다. 또한 항생제와 함께 제조된 PVAc 나노입자에 대한 항생제의 함입은 FT-IR의 CHO, C=O 그리고 OH피크로서 확인하였다. 실험 결과, 단량체 입자의 크기는 균일화 속도 및 유화제와 공유화제의 양에 의하여 조절할 수 있었고, 제조된 고분자 라텍스의 입자크기는 80 ~ 300 nm의 분포를 나타내었다. 또한 공유화제를 사용한 미니유화 중합방법은 전통적인 에멀젼 제조 방법과 비교하여 균일하고 안정한 단량체 입자가 형성되는 것을 확인할 수 있었다. 이는 헥사데칸을 공유화제로 사용함으로써 단량체 입자간의 오스트발드 숙성과 유착을 방지 또는 지연시키기 때문인 것으로 판단된다.

Keywords: miniemulsion polymerization; vinyl acetate; cosurfactant; homogenization; Ostwald ripening

References
  • 1. Barrere M, Landfester K, Polymer, 44(10), 2833 (2003)
  •  
  • 2. Dai L, Li W, Hou X, Colloids Surf. A: Physicochem. Eng. Asp., 125, 27 (1997)
  •  
  • 3. Katsumoto Y, Ushiki H, Graciaa A, Lachaise J, J. Phys.: Condens. Matter., 12, 249 (2000)
  •  
  • 4. Sosa N, Peralta RD, Lopez RG, Ramos LF, Katime I, Cesteros C, Mendizabal E, Puig JE, Polymer, 42(16), 6923 (2001)
  •  
  • 5. Xu XJ, Chew CH, Siow KS, Wong MK, Gan LM, Langmuir, 15(23), 8067 (1999)
  •  
  • 6. Harkins WD, J. Am. Chem. Soc., 69, 1428 (1947)
  •  
  • 7. Chern CS, Chen TJ, Colloids Surf. A: Physicochem. Eng. Asp., 138, 65 (1998)
  •  
  • 8. Landfester K, Tiarks F, Hentze HP, Antonietti M, Macromol. Chem. Phys., 201, 1 (2000)
  •  
  • 9. Erdem B, Sudol ED, Dimonie VL, El-Aasser MS, Macromol. Symp., 155, 181 (2000)
  •  
  • 10. Blythe PJ, Morrison BR, Mathauer KA, Sudol ED, El-Aasser MS, Langmuir, 16(3), 898 (2000)
  •  
  • 11. Aizpurua I, Amalvy JI, Barandiaran MJ, Colloids Surf. A: Physicochem. Eng. Asp., 166, 59 (2000)
  •  
  • 12. Sagitani H, Friberg SE, Lindman BOrganized Solution: Surfactant in Science and Technology, Marcel Dekker, New York (1992)
  •  
  • 13. Kobayashi S, Uyama H, Takamoto T, Biomacromolecules, 1, 3 (2000)
  •  
  • 14. Robinson DA, Bogdanffy MS, Reed CJ, Toxicology, 180, 209 (2002)
  •  
  • 15. Chattopadhyay S, Sivalingam G, Madras G, Polym. Degrad. Stabil.in press
  •  
  • 16. Park SJ, Kim SH, Lee JR, Lee HB, Hong SK, Polym.(Korea), 27(5), 449 (2003)
  •  
  • 17. Lim MS, Chen H, J. Polym. Sci. A: Polym. Chem., 38(10), 1818 (2000)
  •  
  • 18. Asua JM, Prog. Polym. Sci., 27, 1283 (2002)
  •  
  • 19. Landfester K, Bechthold N, Tiarks F, Antonietti M, Macromolecules, 32(16), 5222 (1999)
  •  
  • 20. Kabalnov AS, Shchukin ED, Adv. Colloid Interface Sci., 38, 69 (1992)
  •  
  • 21. Chern CS, Chen TJ, Liou YC, Polymer, 39(16), 3767 (1998)
  •  
  • 22. Tang PL, Sudol ED, Adams ME, Silebi CA, El-Aasser MSPolymer Latexes, American Chemical Society, Washington, D.C. (1992)
  •  
  • 23. Samer CJ, Schork FJ, Ind. Eng. Chem. Res., 38(5), 1801 (1999)
  •  
  • 24. Antonietti M, Landfester K, Proc. Polym. Sci., 27, 689 (2002)
  •  
  • 25. Gooch JW, Dong H, Schork FJ, J. Appl. Polym. Sci., 76(1), 105 (2000)
  •  
  • 26. Landfester K, Macromol. Rapid Commun., 22, 896 (2001)
  •  
  • 27. Park SJ, Brendle M, J. Colloid Interface Sci., 188(2), 336 (1997)
  •  
  • 28. Schork FJ, Poehlein GW, Wang S, Reimers J, Rodrigues J, Samer C, Colloids Surf. A: Physicochem. Eng. Asp., 153, 39 (1999)
  •  
  • 29. Kim A, Park SJ, Lee JR, J. Colloid Interface Sci., 197(1), 119 (1998)
  •  
  • 30. Park SJ, Lee JR, J. Colloid Interface Sci., 219(1), 178 (1999)
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2024 Impact Factor : 0.6
  • Indexed in SCIE

This Article

  • 2004; 28(1): 10-17

    Published online Jan 25, 2004

  • Received on Aug 22, 2003
  • Accepted on Nov 20, 2003