• Preparation of Poly(vinylpyrrolidone) Coated Iron Oxide Nanoparticles for Contrast Agent
  • Lee HY, Lim NH, Seo JA, Khang G, Kim J, Lee HB, Cho SH
  • 조영제로 활용하기 위한 폴리(비닐피롤리돈)이 코팅된 산화철 나노 입자의 제조
  • 이하영, 임낙현, 서진아, 강길선, 김정안, 이해방, 조선행
Abstract
Iron oxide nanoparticles were prepared by the thermal decomposition of iron pentacarbonyl (Fe(CO)5) . Poly(vinylpyrrolidone) (PVP) was used as surface-modifying agent to control the size of the iron oxide nanoparticles. The crystalline structure of PVP coated iron oxide nanoparticles was determined by XRD. The size of PVP coated iron oxide nanoparticles was determined by TEM and ELS. The particle sizes of PVP coated iron oxide nanoparticles were controlled by adjusting the molar ratio of PVP/Fe (CO)5, solvent and molecular weight of PVP. Particle sizes increased with increasing PVP content. Spherical 50100 nm sized iron oxide nanoclusters were produced when dimethylformamide was used as a solvent. And well-defined 10 nm iron oxide nanoparticles were produced in Carbitol. The prepared PVP coated iron oxide nanoparticles exhibited a well-dispersed property in water. The results obtained in this study confirmed the feasibility of the PVP-coated iron oxide nanoparticles as a biomaterial for MRI contrast agent.

Fe(CO)5 (철 펜타카보닐)의 열분해법을 이용하여 산화철 나노 입자를 제조하였다. 표면 조절 시약으로서 생체적 합성 고분자인 폴리(비닐피롤리돈)(PVP)을 사용하여 산화철 나노 입자의 크기를 제어하였다. 산화철 나노 입자의 형성 여부는 XRD를 통해 분석하였으며, PVP 코팅된 산화철 나노 입자의 크기는 TEM, ELS를 통하여 분석하였다. PVP 코팅된 산화철 나노 입자의 입자 크기는 PVP/Fe(CO)5의 몰비와 용매, PVP 분자량에 의해 조절되었다. PVP 함량이 증가함에 따라 입자 크기가 증가하였으며 디메틸포름아마이드를 용매로 하였을 때 50~100 nm의 산화철 나노 클러스터가 형성되었고, Carbitol을 용매로 하였을 때 균일하게 분산된 10 nm 이하의 작은 PVP 코팅된 산화철 나노 입자가 형성되었다. 본 연구에서 제조된 PVP 코팅된 산화철 나노 입자는 물에 잘 분산될 뿐 아니라 생체적합적인 PVP로 코팅이 되었기 때문에 in vivo에 응용할 수 있으며, 입자의 크기가 50~100 nm 및 10 nm로 조절됨으로써 MRI 조영제로서 가능성을 가지고 있음을 확인하였다.

Keywords: iron oxide; nanoparticles; MRI contrast agent; thermal decomposition; poly(vinylpyrrolidone)

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
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This Article

  • 2005; 29(3): 266-270

    Published online May 25, 2005

  • Received on Jan 20, 2005
  • Accepted on Mar 25, 2005