• Synthesis of Molecularly Imprinted Polymers for Chiral (S)-Ibuprofen and Their Molecular Recognition Mechanism
  • Huangfu F, Wang B, Sun Y
  • 키랄(S)-이부푸로펜 함유 고분자의 합성과 제조된 고분자의 분자 인식 메카니즘
  • Huangfu F, Wang B, Sun Y
Abstract
A group of molecularly imprinted polymers (MIPs) with specific recognition for chiral (S)-ibuprofen were successfully prepared based on hydrogen bonds, utilizing α-methacrylic acid as a functional monomer. The IR analysis of MIPs showed that the blue- and red-shifted hydrogen bonds were formed between templates and functional monomers in the process of self-assembly imprinting and re-recognition, respectively. According to UV-Vis analysis, we found that the ratio of host-guest complexes between template molecule and functional monomer was 1:1. The effect of crosslinker's quantity on the polymerization was studied by transmission electron microscope (TEM). The adsorption selectivity experiments indicated that MIPs exhibited higher selectivity to (S)-ibuprofen than those to ketoprofen and (R)-ibuprofen, (S)-ibuprofen's structural analogs.

Keywords: (S)-ibuprofen; molecularly imprinted polymer; chiral separation; hydrogen bond; separation factor.

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  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2024 Impact Factor : 0.6
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This Article

  • 2013; 37(3): 288-293

    Published online May 25, 2013

  • Received on Sep 6, 2012
  • Accepted on Dec 2, 2012