Article
  • Coaxial Capillary Microfluidic Chips Modified with Poly(vinyl alcohol) for the Long-term Production of Uniform Oil Droplets

  • Guk-Young Ahn*, **,# , Inseong Choi*, **,# , Se Hee Hwang*, **, Jong Hwa Seo*, **, Eun Seo Kim*, **, Do-Hyun Oh*, **, Young-Hyun Ryu*, **, Min-Ho Kang*, **,† , and Sung-Wook Choi*, **,†

  • *Biomedical and Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 14662, Korea
    **Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 14662, Korea

  • 균일한 에멀젼의 연속 생산을 위해 폴리비닐 알코올로 개질한 동축 정렬 캐필러리 미세유체장치

  • 안국영*, **,# · 최인성*, **,# · 황세희*, ** · 서종화*, ** · 김은서*, ** · 오도현*, ** · 류영현*, ** · 강민호*, **,† · 최성욱*, **,†

  • *가톨릭대학교 바이오메디컬화학공학과, **가톨릭대학교 생명공학과

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

Abstract

Coaxially aligned microfluidic devices were fabricated using a round silica microcapillary and a square glass capillary with different inner diameters (200 and 300 µm). The inner wall of the square glass capillary was modified with poly(vinyl alcohol) (PVA) through plasma treatment to provide a hydrophilic surface. The microfluidic device consisting of the glass capillary with the smaller inner diameter demonstrated uniform oil droplet formation, compared to that with the larger inner diameter. The production of uniform droplets and microspheres originated from the coaxial alignment of the silica microcapillary with the square glass capillary. The glass substrate treated by plasma and PVA modification exhibited a hydrophilic surface, resulting in more stable uniform droplet formation for 6 h. The microfluidic device with PVA-coated glass capillary can be potentially used as a platform for the reproducible and reliable production of uniform oil droplets for a long period of time.


50 μm의 내경과 150 μm의 외경을 갖는 원형 실리카 캐필러리와 200 혹은 300 μm의 내경을 갖는 정사각형 유리 캐필러리를 사용하여 동축으로 정렬된 미세유체장치를 제작하였다. 실리카 캐필러리와 유리 캐필러리의 동축 정렬이 200 μm의 내경을 갖는 유리 캐필러리에서 더 유리하였으며, 300 μm 내경 보다 균일한 에멀젼 형성이 가능하였다. 장시간 에멀젼 형성 실험에서 폴리비닐 알코올로 친수성 개질된 유리 캐필러리를 사용할 경우 6시간 동안 안정적이고 균일한 에멀젼 형성이 가능하였다. 본 연구에서 제조한 폴리비닐 알코올로 표면 개질된 유리 캐필러리와 실리카 캐필러리를 이용한 미세유체장치는 장시간 동안 균일한 에멀젼을 제조하기 위한 플랫폼으로 활용될 수 있다.


Keywords: silica capillary, square capillary, microfluidic device, emulsion, modification.

  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2023; 47(5): 582-589

    Published online Sep 25, 2023

  • 10.7317/pk.2023.47.5.582
  • Received on Mar 7, 2023
  • Revised on May 29, 2023
  • Accepted on Jul 28, 2023

Correspondence to

  • Min-Ho Kang. Sung-Wook Choi

  • *Biomedical and Chemical Engineering, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 14662, Korea
    **Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi-do 14662, Korea

  • E-mail: mhkang@catholic.ac.kr, choisw@catholic.ac.kr