Article
  • Effect of Polyethylene Glycol (PEG) and Hydroxypropylmethylcellulose (HPMC) on the Dissolution Rate of a Sustained Release Rebamipide Tablet

  • Ju-Ah Sim and Seh Hyon Song†

  • College of Pharmacy, Kyungsung University, 309 Suyeong-ro, Nam-gu, Busan 48434, Korea

  • 폴리에틸렌글리콜 및 히드록시프로필메틸셀룰로오스가 레바미피드 서방성 정제의 용출에 미치는 영향

  • 심주아 · 송세현†

  • 경성대학교 약학대학

  • Reproduction, stored in a retrieval system, or transmitted in any form of any part of this publication is permitted only by written permission from the Polymer Society of Korea.

References
  • 1. Shay, H. Etiology of Peptic Ulcer Disease. Am. J. Digest. Dis. 1961, 6, 29-49.
  •  
  • 2. Bright-Asare, P. Treatment of Duodenal Ulcer with Enprostil, a Prostaglandin E2 Analogue. Am. J. Med. 1986, 18, 64-68.
  •  
  • 3. Naito, Y.; Yoshikawa, T.; Iinuma, S.; Miyazaki, R.; Yoshida, N.; Osumi, T.; Hirao, Y.; Kondo, M. Local Gastric and Serum Concentrations of Rebamipide following Oral Administration to Patients with Chronic Gastritis. Arzneim, Forsch. Drug Res. 1996, 46, 698-700.
  •  
  • 4. Shioya, Y.; Shimizu, T. High-performance Liquid Chromatographic Procedure for the Determination of a New Antigastric Ulcer agent, 2-(4-Chlorobenzoylamino)-3-[2(1H)-Quinolinon-4-yl]Propionic Acid, in Human Plasma and Urine. J. Chromatogr. 1988, 434, 283-287.
  •  
  • 5. Huang, B.; Li, G.; Luo, J.; Duan, L.; Nobuaki, K.; Akira, Y. Permeabilities of Rebamipide via Rat Intestinal Membranes and Its Colon Specific Delivery Using Chitosan Capsule as a Carrier. World. J. Gastroenterol. 2008, 14, 4928-4937.
  •  
  • 6. Markovic, M.; Zur, M.; Dahan, A.; Cvijić, S. Biopharmaceutical Characterization of Rebamipide: The Role of Mucus Binding in Regional-dependent Intestinal Permeability. Eur. J. Pharm. Sci. 2020, 152, 105440.
  •  
  • 7. Rouge, N.; Buri, P.; Doelker, E. Drug Absorption Sites in the Gastrointestinal Tract and Dosage Forms for Site-specific Delivery. Int. J. Pharm. 1996, 136, 117-139.
  •  
  • 8. Chien, W. Y. Potential Development and New Approaches in Oral Controlled-Release Drug Delivery Systems. Drug Dev. Ind. Pharm. 2008, 9, 1291-1330.
  •  
  • 9. Grassi, M.; Grassi, G. Application of Mathematical Modeling in Sustained Release Delivery Systems. Expert Opin. Drug Deliv. 2014, 11, 1299-1321.
  •  
  • 10. Sousa, A.; Serra, J.; Estevens, C.; Costa, R.; Ribeiro, A. A Quality by Design Approach in Oral Extended Release Drug Delivery Systems: Where We Are and Where We Are Going? J. Pharm. Investig. 2023, 53, 269-306.
  •  
  • 11. Gao, Y.; Gesenberg, C.; Zheng, W. Developing Solid Oral Dosage Forms; Academic Press: London, 2017.
  •  
  • 12. Bermejo, M.; Sanchez-Dengra, B.; Gonzalez-Alvarez, M.; Gonzalez-Alvarez, I. Oral Controlled Release Dosage Forms: Dissolution versus Diffusion, Expert Opin. Drug Deliv. 2020, 17, 791-803.
  •  
  • 13. Song, S. H.; Chae, B. R.; Sohn, S. I.; Yeom, D. W.; Son, H. Y.; Kim., J. H.; Kim, S. R.; Lee, S. G.; Choi, Y. W. Formulation of Controlled-release Pelubiprofen Tablet Using Kollidon SR. Int. J. Pharm. 2016, 511, 864-875.
  •  
  • 14. Sinko, P. Martin’s Physical Pharmacy and Pharmaceutical Sciences 8th Edition; LWW: Philadelphia, 2023.
  •  
  • 15. Lamoudi, L.; Chaumeil, J. C.; Daoud, K. Swelling, Erosion and Drug Release Characteristics of Sodium Diclofenac from Heterogeneous Matrix Tablets. J. Drug Deliv. Sci. Technol. 2016, 31, 93-100.
  •  
  • 16. Sheskey, P. J.; Hancock, B. C.; Moss, G. P.; Goldfarb, D. J. Handbook of Pharmaceutical Excipients 9th Edition; Pharmaceutical Press: London, 2020.
  •  
  • 17. Losi, E.; Peppas, N. A.; Ketcham, R. A.; Colombo, G.; Bettini1, R.; Sonvico, F.; Colombo, P. Investigation of the Swelling Behavior of Dome Matrix Drug Delivery Modules by High-resolution X-ray Computed Tomography. J. Drug Del. Sci. Tech. 2013, 23, 165-170.
  •  
  • 18. Leleux, J.; Williams, R. O. Recent Advancements in Mechanical Reduction Methods: Particulate Systems. Drug Dev. Ind. Pharm. 2013, 40, 289-300.
  •  
  • 19. BENEO GmbH. Technical literature: Isomalt, galenIQ; BENEO GmbH: Mannheim, 2019.
  •  
  • 20. Williams, H. D.; Ward, R.; Culy, A.; Hardy, I. J.; Melia, C. D. Designing HPMC Matrices with Improved Resistance to Dissolved Sugar. Int. J. Pharm. 2010, 401, 51-59.
  •  
  • 21. Costa, P.; Lobo, J. M. S. Influence of Dissolution Medium Agitation on Release Profiles of Sustained-Release Tablets. Drug. Dev. Ind. Pharm. 2001, 27, 811-817.
  •  
  • 22. Mitchell, S. A.; Reynolds, T. D.; Dasbach, T. P. A Compaction Process to Enhance Dissolution of Poorly Water-soluble Drugs Using Hydroxypropyl Methylcellulose. Int. J. Pharm. 2003, 250, 3-11.
  •  
  • 23. Heo, M.; Piao, Z.; Kim, T.; Cao, Q.; Kim, A.; Lee, B. Effect of Solubilizing and Microemulsifying Excipients in Polyethylene Glycol 6000 Solid Dispersion on Enhanced Dissolution and Bioavailability of Ketoconazole. Arch. Pharm. Res. 2005, 5, 604-611.
  •  
  • 24. Chidambaram, N.; Porter W.; Flood, K.; Qiu, Y. Formulation and Characterization of New Layered Diffusional Matrices for Zero-order Sustained Release. J. Control. Release. 1998, 52, 149-158.
  •  
  • Polymer(Korea) 폴리머
  • Frequency : Bimonthly(odd)
    ISSN 0379-153X(Print)
    ISSN 2234-8077(Online)
    Abbr. Polym. Korea
  • 2022 Impact Factor : 0.4
  • Indexed in SCIE

This Article

  • 2024; 48(1): 53-59

    Published online Jan 25, 2024

  • 10.7317/pk.2024.48.1.53
  • Received on Sep 6, 2023
  • Revised on Oct 18, 2023
  • Accepted on Oct 20, 2023

Correspondence to

  • Seh Hyon Song

  • College of Pharmacy, Kyungsung University, 309 Suyeong-ro, Nam-gu, Busan 48434, Korea

  • E-mail: shsong@ks.ac.kr